Description
The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals.
- Optimized for CNS use
- Ideal for chronic implantation
- Available membrane: PAES, 20kDA MWCO or PES, 100 kDA MWCO
- Membrane lengths: 1, 2, 3 or 4 mm
- Membrane diameter: 0.5 mm
- Available metal free
Item Listing
| Item# | Description | Price | Quantity |
|---|---|---|---|
| CMA8010431 | CMA 12 Elite Probe – 1 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8010432 | CMA 12 Elite Probe – 2 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8010433 | CMA 12 Elite Probe – 3 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8010434 | CMA 12 Elite Probe – 4 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8309661 | CMA 12 HighCO Probe – 1 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8309662 | CMA 12 HighCO Probe – 2 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8309663 | CMA 12 HighCO Probe – 3 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8309664 | CMA 12 HighCO Probe – 4 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8011201 | CMA 12 Elite Metal Free Probe -1 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8011202 | CMA 12 Elite Metal Free Probe – 2 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8011203 | CMA 12 Elite Metal Free Probe – 3 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8011204 | CMA 12 Elite Metal Free Probe – 4 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8011221 | CMA 12 HighCO Metal Free Probe – 1 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8011222 | CMA 12 HighCO Metal Free Probe – 2 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8011223 | CMA 12 HighCO Metal Free Probe – 3 mm (pkg. of 3) | Request a Quote | Request a Quote |
| CMA8011224 | CMA 12 HighCO Metal Free Probe – 4 mm (pkg. of 3) | Request a Quote | Request a Quote |
Full Description
The CMA 12 Microdialysis Probe is ideal for stereotaxic work in the CNS of anesthetized or conscious animals.
A semi-permeable membrane is glued between the tip of the inner steel cannnula and the outer steel shaft. The perfusion fluid enters the membrane space through two holes in the inner cannula and flows into the shaft to the outlet.
All metal parts are treated to prevent oxidation of labile compounds in the perfusate. The membrane is available in both 20 000 and 100 000 Daltons cut-off as standard. The inlet/outlet capillaries are mounted in a blue plastic body matched to the size of a corresponding CMA 12 guide cannula.
Once implanted, the probe sits tightly in the guide cannula´s capsule without the need for screwing or cementing. FEP tubing can be connected to the probe using tubing adaptors. The CMA 12 Microdialysis Probes are guaranteed for single use, however, with proper care, they may be reused several times. Complete instructions are included.
Specifications
| Specifications | CMA8010431 | CMA8010432 | CMA8010433 | CMA8010434 | CMA8309661 | CMA8309662 | CMA8309663 | CMA8309664 |
|---|---|---|---|---|---|---|---|---|
| Membrane Length | 1 mm | 2 mm | 3 mm | 4 mm | 1 mm | 2 mm | 3 mm | 4 mm |
| Membrane O D | 0.5 mm | 0.5 mm | 0.5 mm | 0.5 mm | 0.5 mm | 0.5 mm | 0.5 mm | 0.5 mm |
| Membrane Material | PAES | PAES | PAES | PAES | PES | PES | PES | PES |
| Molecular Weight Cut-off | 20 kDA MWCO | 20 kDA MWCO | 20 kDA MWCO | 20 kDA MWCO | 100 kDA MWCO | 100 kDA MWCO | 100 kDA MWCO | 100 kDA MWCO |
| Shaft Diameter | 0.64 mm | 0.64 mm | 0.64 mm | 0.64 mm | 0.64 mm | 0.64 mm | 0.64 mm | 0.64 mm |
| Shaft Length Metric | 14 mm | 14 mm | 14 mm | 14 mm | 14 mm | 14 mm | 14 mm | 14 mm |
| Intlet Internal Volume | negligible | negligible | negligible | negligible | negligible | negligible | negligible | negligible |
| Outlet Internal Volume | 0.3 µL | 0.3 µL | 0.3 µL | 0.3 µL | 0.3 µ | 0.3 µ | 0.3 µ | 0.3 µ |
| Model | Standard | Standard | Standard | Standard | Standard | Standard | Standard | Standard |
Journal Articles
Gottås A, Ripel Å, Boix F, Vindenes V, Mørland J, Øiestad EL. (2015 ) Determination of dopamine concentrations in brain extracellular fluid using microdialysis with short sampling intervals, analyzed by ultra high performance liquid chromatography ta J Pharmacol Toxicol Methods.
Selected Recent Publications
Paasonen, J. et al., 2017. Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat. Neuropharmacology, 119, pp.15–25.
Kealy, J. et al., 2017. Real-time changes in hippocampal energy demands during a spatial working memory task. Behavioural Brain Research, 326, pp.59–68.
Alves, I.A. et al., 2017. Influence of Experimental Cryptococcal Meningitis in Wistar Rats on Voriconazole Brain Penetration Assessed by Microdialysis. Antimicrobial Agents and Chemotherapy, p.AAC.00321-17.
Jin, W.-S. et al., 2017. Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model. Acta Neuropathologica, pp.1–14.
Kurosawa, T. et al., 2017. Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells. Journal of Pharmaceutical Sciences, 0(0). Available at: http://jpharmsci.org/article/S0022-3549(17)30267-8… [Accessed May 14, 2017].
Bank, J.H.H. et al., 2017. Gene expression analysis and microdialysis suggest hypothalamic triiodothyronine (T3) gates daily torpor in Djungarian hamsters (Phodopus sungorus). Journal of Comparative Physiology B, pp.1–12.
Miller, S. et al., 2017. Therapeutic Uses Of Compounds Having Affinity To The Serotonin Transporter, Serotonin Receptors and Noradrenalin Transporter. Available at: http://www.freepatentsonline.com/y2017/0087138.html [Accessed May 14, 2017].
Wang, W. et al., 2017. Effect of Efflux Transporter Inhibition on the Distribution of Fluconazole in the Rat Brain. Neurochemical Research, pp.1–8.
Mørk, A. et al., 2017. Effects of the 5-HT6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex. European Journal of Pharmacology, 799, pp.1–6.
Takeda, A. et al., 2017. Characteristic of Extracellular Zn2+ Influx in the Middle-Aged Dentate Gyrus and Its Involvement in Attenuation of LTP. Molecular Neurobiology, pp.1–11.
